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KMID : 0359320090490010073
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Korean Journal of Veterinary Research
2009 Volume.49 No. 1 p.73 ~ p.78
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Discoid lupus erythematosus (DLE) in a juvenile Alaskan Malamute dog
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Park Hee-Myung
Lee Jong-Hwan
Lim Chae-Young
Park Chul
Kim Ju-Won
Yoo Jong-Hyun
Kim Ha-Jung
Fu-Shi Quan
Quan Fu-Shi
Lim Chae-Young
Park Chul
Kim Ju-Won
Yoo Jong-Hyun
Kim Ha-Jung
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Abstract
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Discoid lupus erythematosus (DLE) is an immune-mediated skin disease which requires histopathology and immunohistopathology in both dogs and humans. A 10-month-old, intact female Alaskan Malamute presented for depigmentation, swelling, alopecia, erythema, and crusting on the bridge of the nose and the nasal planum. Cytological examination of nasal lesions revealed numerous cocci and neutrophils. Histopathological features included of infiltration of mononuclear cells at the dermoepidermal junction. Direct immunofluorescence tests and immunohistochemistry exhibited positive IgG, IgM, IgA, CD3, CD18, and CD79a on the epidermal basement membranes and around adnexal glands. This case indicates both T cells and B cells are related to mechanism of canine DLE. This case report describes advanced diagnostic tests and clinical outcome with immune suppressive therapy in a rare juvenile canine DLE case.
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KEYWORD
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discoid lupus erythematosus, dog, immunohistochemistry, immunohistopathology
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